Keith Willson. Xun Jia. Siyong Kim. Shirley Lehnert. Michael Ljungberg. Home Contact us Help Free delivery worldwide. Free delivery worldwide. Bestselling Series. Harry Potter. Popular Features. New Releases. Description Gamma cameras are traditionally large devices that are situated in nuclear medicine departments, but recent advances in detector design have enabled the production of compact gamma cameras that allow nuclear imaging at the patient bedside and in the operating theatre. Gamma Cameras for Interventional and Intraoperative Imaging is the first book to cover this new area of imaging, and provides a unique insight into the experimental and clinical use of small field of view gamma cameras in hospitals.
This book explores advances in the design and operation of compact gamma cameras and conducts a thorough review of current SFOV systems, before exploring the clinical applications of the technology. It is an essential reference for surgeons, operating theatre staff, clinical scientists medical physicists , technologists, nuclear physicians and radiologists whose patients could benefit from this technology. Product details Format Hardback pages Dimensions x x Other books in this series. Add to basket. Medical Equipment Management Keith Willson.
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Table of contents Advances in Detector Design and Operation. Mobile Gamma Cameras. Review of Intraoperative Camera Systems. Hybrid Imaging Systems. Radiopharmaceuticals for Intraoperative Imaging. Hybrid Tracers. Intraoperative Nuclear Imaging. Overview of the acquired images. Placement of the tracker on the rigid skull and outside the surgical field prevented the need for replacement during the surgical procedure and resulted in minimal deformations. It should be noted that this inaccuracy seemed to be influenced for a large part by the mere 3-mm spatial resolution of the freehandSPECT images [ 23 ].
Inaccuracy induced by movement artifacts could be contributed to e. In all cases wherein the navigation procedure was slightly inaccurate, identification of the SNs was enabled by a manual correction based on fluorescence imaging. Intraoperative navigation procedure. In patients 1 and 6, the superior spatial resolution of fluorescence imaging allowed localization of the SNs that were not detected by freehandSPECT. Pathological evaluation of the biopsy specimens resulted in identification of a total of 24 nodes, of which two were tumor-positive found in patients 5 and 8; Table 1.
In patient 8, a tumor-positive SN was found in the parotid gland, while in patient 5, a tumor-positive node was located in the re-excision specimen of the melanoma scar. This last node was overshadowed by the high-activity of the injection site, which prevented identification on preoperative images and was therefore not explored during the operation. The use of the hybrid tracer ICG- 99m Tc-nanocolloid allowed for the high-resolution detection of the remaining SNs using fluorescence imaging. During the surgical procedure, the freehandSPECT device helped to place the nuclear medicine findings within the anatomical context.
In addition, the use of an augmented reality overlay also provided dynamic information with regard to the distance to the target. Unfortunately, intraoperative use of freehandSPECT did not demonstrate the resolution and real-time confirmation that is required to solve this issue. Hence, resection of all SNs in one hotspot still demands the use of high-resolution and real-time feedback, as is provided by fluorescence imaging. This practical limitation was now overcome by the use of intraoperatively generated freehandSPECT scans.
The disruption of the surgical workflow was minimized by the prior knowledge of the location wherein the SNs resided.
Such disruption, however, remains common during the introduction of new technologies and can be contributed to the early stage development of the technology as well as the limited experience with the technology learning curve. It may be envisioned that integration of the freehandSPECT and navigation options in the surgical workflow can be optimized further from a technical point of view. For example, prevention of duplication of modalities see Table 3 would already save time. Based on the fact that surgeons used the depth estimation provided by the navigation setup to estimate the risk of damage to delicate tissues, one may also reason that striking a balance between cure- and surgery-induced toxicity would warrant a slight prolongation of the surgical procedure.
The use of the hybrid tracer ICG- 99m Tc-nanocolloid , a tracer that can be detected using both modalities [ 24 ], enabled complementary use of nuclear and fluorescent technologies. In the current study, a gamma probe was used for navigation, but in the future, other tools may be positioned using navigation, for example, a fluorescence camera that displays a real-time augmented reality overlay of freehandSPECT data within the fluorescence images see Table 3 [ 26 ].
In such an integrated image guided surgery approach, the use of augmented reality displays, virtual navigation, and fluorescence guidance can all be used in the same setting [ 29 ].
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The augmented reality display and directional positioning options provided by the navigation system help refine lesion localization, compared to traditional radioguided surgery tools. Implications of the MSLT-1 for sentinel lymph node biopsy in cutaneous head and neck melanoma.
Oral Oncol. Sentinel node biopsy for head and neck melanoma: a systematic review. Otolaryngol Head Neck Surg.
The definition of a sentinel node. Ann Surg Oncol. A comprehensive overview of radioguided surgery using gamma detection probe technology. World J Surg Oncol. Tsuchimochi M, Hayama K. Intraoperative gamma cameras for radioguided surgery: technical characteristics, performance parameters, and clinical applications. Phys Med. The next evolution in radioguided surgery: breast cancer related sentinel node localization using a freehandSPECT-mobile gamma camera combination. Detecting near-the-injection-site sentinel nodes in head and neck melanomas with a high-resolution portable gamma camera.
Clin Nucl Med. A new portable hybrid camera for fused optical and scintigraphic imaging: first clinical experiences. J Nucl Med. A hybrid camera for simultaneous imaging of gamma and optical photons. J Instrum. Intraoperative 3-D imaging improves sentinel lymph node biopsy in oral cancer.
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Head Neck. IEEE; ;—8. Fusion of freehand SPECT and ultrasound to perform ultrasound-guided fine-needle aspiration cytology of sentinel nodes in head and neck cancer. Clin Otolaryngol.
Gamma Cameras for Interventional and Intraoperative Imaging
Multimodal surgical guidance during sentinel node biopsy for melanoma: combined gamma tracing and fluorescence imaging of the sentinel node through use of the hybrid tracer indocyanine green- 99m Tc-nanocolloid. Surgical navigation: an overview of the state-of-the-art clinical applications. Radioguided surgery. Springer International Publishing; A portable gamma-camera for intraoperative detection of sentinel nodes in the head and neck region.
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Expert Rev Med Devices. Image navigation as a means to expand the boundaries of fluorescence-guided surgery. Phys Med Biol. Feasibility of intraoperative navigation to the sentinel node in the groin using preoperatively acquired single photon emission computerized tomography data: transferring functional imaging to the operating room. J Urol. Towards hybrid navigation of a fluorescence camera in an open surgery setting. Nucl Med Commun. Sentinel lymph node biopsy for prostate cancer: a hybrid approach.
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Near-infrared fluorescence guided surgery under ambient light conditions, a next step to embedment of the technology in clinical routine. Download references. GHK and NSvdB are performed the quality control of data and algorithms, data analysis and interpretation, and statistical analysis. All authors reviewed and edited the manuscript. All authors read and approved the final manuscript. Correspondence to Fijs W. Followed procedures were in accordance with the ethical standards of the responsible committee on human experimentation institutional and national and with the Helsinki declaration of , as revised in
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